abstract：:Vocal fold lamina propria extracellular matrix (ECM) is highly aligned and when injured, becomes disorganized with loss of the tissue's critical biomechanical properties. This study examines the effects of electrospun fiber scaffold architecture and elastin-like polypeptide (ELP4) coating on human vocal fold fibroblas...

journal_title：Acta biomaterialia

authors： Hughes LA,Gaston J,McAlindon K,Woodhouse KA,Thibeault SL

更新日期：2015-02-01 00:00:00

abstract：:Injectable biomaterials are attractive for soft tissue regeneration because they are handled in a minimally invasive manner and can easily adapt to complex defects. However, inadequate vascularization of the injectable constructs has long been a barrier, leading to necrosis or volume reduction after implantation. In t...

journal_title：Acta biomaterialia

authors： Li Z,Qu T,Ding C,Ma C,Sun H,Li S,Liu X

更新日期：2015-02-01 00:00:00

abstract：:The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap. Many current strategies to stimulate regeneration take inspiration from this biological response. However, little is known about the balance of cell-matrix and Schw...

journal_title：Acta biomaterialia

authors： Romano NH,Madl CM,Heilshorn SC

更新日期：2015-01-01 00:00:00

abstract：:Novel porous bilayered scaffolds, fully integrating a silk fibroin (SF) layer and a silk-nano calcium phosphate (silk-nanoCaP) layer for osteochondral defect (OCD) regeneration, were developed. Homogeneous porosity distribution was achieved in the scaffolds, with calcium phosphate phase only retained in the silk-nanoC...

journal_title：Acta biomaterialia

authors： Yan LP,Silva-Correia J,Oliveira MB,Vilela C,Pereira H,Sousa RA,Mano JF,Oliveira AL,Oliveira JM,Reis RL

更新日期：2015-01-01 00:00:00

abstract：:A novel processing route was proposed for the fabrication of biodegradable Mg-Ca binary alloys with high Ca contents (2-3 wt.%) in sheet form with enhanced biocorrosion resistance by tailoring their microstructures. The effective refinement and dispersion of the Mg2Ca phase in the Mg-Ca alloys using extrusion followed...

journal_title：Acta biomaterialia

authors： Seong JW,Kim WJ

更新日期：2015-01-01 00:00:00

abstract：:The functional requirements of regenerated calcified tissues are that they enable the tissues to bear a variety of imposed stress and consequent contact-induced strain without substantial fracture. Here we demonstrate the effects of glucocorticoid hormones such as dexamethasone and hydrocortisone on the nanomechanical...

journal_title：Acta biomaterialia

authors： Miyamoto S,Miyamoto Y,Shibata Y,Yoshimura K,Izumida E,Suzuki H,Miyazaki T,Maki K,Kamijo R

更新日期：2015-01-01 00:00:00

abstract：:The macrophysical properties of granular biomaterials used to fill bone defects have rarely been considered. Granules of a given biomaterial occupy three-dimensional (3-D) space when packed together and create a macroporosity suitable for the invasion of vascular and bone cells. Granules of β-tricalcium phosphate were...

journal_title：Acta biomaterialia

authors： Ndiaye M,Terranova L,Mallet R,Mabilleau G,Chappard D

更新日期：2015-01-01 00:00:00

abstract：:A novel bactericidal material comprising rod-shaped core-shell-shell Au-Ag-Au nanorods is constructed as a nanoheater in the near-infrared (NIR) region. The outer Au shell melts under laser irradiation and results in exposure of the inner Ag shell, facilitating the controlled release of the antibacterial Ag shell/laye...

journal_title：Acta biomaterialia

authors： Hu B,Wang N,Han L,Chen ML,Wang JH

更新日期：2015-01-01 00:00:00

abstract：:Natural silk fiber spun by the silkworm Bombyx mori is widely used not only for textile materials, but also for biofunctional materials. In the present study, we genetically engineered an advanced silk material, named hSFSV, using a transgenic silkworm, in which the recombinant human acidic fibroblast growth factor (h...

journal_title：Acta biomaterialia

authors： Wang F,Xu H,Wang Y,Wang R,Yuan L,Ding H,Song C,Ma S,Peng Z,Peng Z,Zhao P,Xia Q

更新日期：2014-12-01 00:00:00

abstract：:Bioactive materials play an important role in facilitating dental pulp repair when living dental pulp is exposed after injuries. Mineral trioxide aggregate is the currently recommended material of choice for pulp repair procedures though has several disadvantages, especially the inconvenience of handling. Little infor...

journal_title：Acta biomaterialia

authors： Zhu L,Yang J,Zhang J,Lei D,Xiao L,Cheng X,Lin Y,Peng B

更新日期：2014-12-01 00:00:00

abstract：:Anisotropic scaffolds with the typical structure of lamellar, aligned and continuous pores were successfully achieved by the directional solidification of water-based β-tricalcium phosphate (β-TCP) suspensions. Adjustable porosities from 49 to 82%, tunable pore widths from 8 to 50μm and linked ceramic cells with wall ...

journal_title：Acta biomaterialia

authors： Flauder S,Gbureck U,Müller FA

更新日期：2014-12-01 00:00:00

abstract：:Cell transplantation therapies to treat diseases related to dysfunction of retinal ganglion cells (RGCs) are limited in part by an inability to navigate to the optic nerve head within the retina. During development, RGCs are guided by a series of neurotrophic factors and guidance cues; however, these factors and their...

journal_title：Acta biomaterialia

authors： Kador KE,Alsehli HS,Zindell AN,Lau LW,Andreopoulos FM,Watson BD,Goldberg JL

更新日期：2014-12-01 00:00:00

abstract：:Small intestine submucosa (SIS) has emerged as one of a number of naturally derived extracellular matrix (ECM) biomaterials currently in clinical use. In addition to clinical applications, ECM materials form the basis for a variety of approaches within tissue engineering research. In our preliminary work it was found ...

journal_title：Acta biomaterialia

authors： Syed O,Walters NJ,Day RM,Kim HW,Knowles JC

更新日期：2014-12-01 00:00:00

abstract：:Infection is a major cause of failure of inserted or implanted biomedical devices (biomaterials). During surgery, bacteria may adhere to the implant, initiating biofilm formation. Bacteria are also observed in and recultured from the tissue surrounding implants, and may even reside inside host cells. Whether these bac...

journal_title：Acta biomaterialia

authors： Riool M,de Boer L,Jaspers V,van der Loos CM,van Wamel WJB,Wu G,Kwakman PHS,Zaat SAJ

更新日期：2014-12-01 00:00:00

abstract：:Biomaterial-mediated controlled release of soluble signaling molecules is a tissue engineering approach to spatially control processes of inflammation, microvascular remodeling and host cell recruitment, and to generate biochemical gradients in vivo. Lipid mediators, such as sphingosine 1-phosphate (S1P), are recogniz...

journal_title：Acta biomaterialia

authors： Ogle ME,Sefcik LS,Awojoodu AO,Chiappa NF,Lynch K,Peirce-Cottler S,Botchwey EA

更新日期：2014-11-01 00:00:00

abstract：:This study reports the use of variants of coherent anti-Stokes Raman scattering (CARS) microscopy as a novel method for improved physicochemical characterization of drug-loaded silica particles. Ordered mesoporous silica is a biomaterial that can be loaded to carry a number of biochemicals, including poorly water-solu...

journal_title：Acta biomaterialia

authors： Fussell AL,Mah PT,Offerhaus H,Niemi SM,Salonen J,Santos HA,Strachan C

更新日期：2014-11-01 00:00:00

abstract：:Biomolecular signals within the native extracellular matrix are complex, with bioactive factors found in both soluble and sequestered states. In the design of biomaterials for tissue engineering applications it is increasingly clear that new approaches are required to locally tailor the biomolecular environment surrou...

journal_title：Acta biomaterialia

authors： Alsop AT,Pence JC,Weisgerber DW,Harley BAC,Bailey RC

更新日期：2014-11-01 00:00:00

abstract：:There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing combinations of bioactive growth factors, rather than individual molecu...

journal_title：Acta biomaterialia

authors： Smith EL,Kanczler JM,Gothard D,Roberts CA,Wells JA,White LJ,Qutachi O,Sawkins MJ,Peto H,Rashidi H,Rojo L,Stevens MM,El Haj AJ,Rose FR,Shakesheff KM,Oreffo RO

更新日期：2014-10-01 00:00:00

abstract：:Standard reconstructive procedures for restoring normal function after skeletal muscle defects involve the use of existing host tissues such as muscular flaps. In many instances, this approach is not feasible and delays the rehabilitation process and restoration of tissue function. Currently, cell-based tissue enginee...

journal_title：Acta biomaterialia

authors： Ju YM,Atala A,Yoo JJ,Lee SJ

更新日期：2014-10-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are an exciting cell source as they offer an unlimited supply of cells that can differentiate into all cell types for regenerative medicine applications. To date, there has been no report on hESCs with calcium phosphate cement (CPC) scaffolds for bone regeneration in vivo. The object...

journal_title：Acta biomaterialia

authors： Liu X,Wang P,Chen W,Weir MD,Bao C,Xu HH

更新日期：2014-10-01 00:00:00

abstract：:Dentin contains 1-2μm diameter tubules extending from the pulp cavity to near the junction with enamel. Peritubular dentin (PTD) borders the tubule lumens and is surrounded by intertubular dentin (ITD). Differences in PTD and ITD composition and microstructure remain poorly understood. Here, a (∼200nm)(2), 10.1keV syn...

journal_title：Acta biomaterialia

authors： Stock SR,Deymier-Black AC,Veis A,Telser A,Lux E,Cai Z

更新日期：2014-09-01 00:00:00

abstract：:Eggshell membrane (ESM) is a unique biomaterial, which is generally considered as waste. However, it has extraordinary properties which can be utilized in various fields and its potential applications are therefore now being widely studied. The first part of this review focuses on the chemical composition and morpholo...

journal_title：Acta biomaterialia

authors： Baláž M

更新日期：2014-09-01 00:00:00

abstract：:A critical challenge to regenerating close mimics of native axonal pathways under chronic neurodegenerative disease or injury conditions is the inability to stimulate, sustain and steer neurite outgrowth over a long distance, until they reach their intended targets. Understanding neurite outgrowth necessitates quantit...

journal_title：Acta biomaterialia

authors： Kothapalli CR,Honarmandi P

更新日期：2014-08-01 00:00:00

abstract：:Full-length versions of the four main components of silk cocoons of Vespa simillima hornets, Vssilk1-4, were produced as recombinant proteins in Escherichia coli. In shake flasks, the recombinant Vssilk proteins yielded 160-330mg recombinant proteinl(-1). Films generated from solutions of single Vssilk proteins had a ...

journal_title：Acta biomaterialia

authors： Kambe Y,Sutherland TD,Kameda T

更新日期：2014-08-01 00:00:00

abstract：:Periodontal diseases like periodontitis and peri-implantitis have been linked with Gram-negative anaerobes. The incorporation of various chemotherapeutic agents, including metal ions, into several materials and devices has been extensively studied against periodontal bacteria, and materials doped with metal ions have ...

journal_title：Acta biomaterialia

authors： Goudouri OM,Kontonasaki E,Lohbauer U,Boccaccini AR

更新日期：2014-08-01 00:00:00

abstract：:Meniscal tears are the most common orthopedic injuries to the human body, yet the current treatment of choice is a partial meniscectomy, which is known to lead to joint degeneration and osteoarthritis. As a result, there is a significant clinical need to develop materials capable of restoring function to the meniscus ...

journal_title：Acta biomaterialia

authors： Holloway JL,Lowman AM,VanLandingham MR,Palmese GR

更新日期：2014-08-01 00:00:00

abstract：:Functionalization of polymeric biomaterials permits the conjugation of cell signaling molecules capable of directing cell function. In this study, l-phenylalanine and l-aspartic acid were used to synthesize poly(ester amide)s (PEAs) with pendant carboxylic acid groups through an interfacial polycondensation approach. ...

journal_title：Acta biomaterialia

authors： Knight DK,Gillies ER,Mequanint K

更新日期：2014-08-01 00:00:00

abstract：:There is an increasing clinical need to design novel dental materials that combine regenerative and antibacterial properties. In this work the characterization of a recently developed sol-gel-derived bioactive glass ceramic containing silver ions (Ag-BG) is presented. The microstructural characteristics, ion release p...

journal_title：Acta biomaterialia

authors： Chatzistavrou X,Fenno JC,Faulk D,Badylak S,Kasuga T,Boccaccini AR,Papagerakis P

更新日期：2014-08-01 00:00:00

abstract：:Biomaterial-associated infection is one of the most common complications related to the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally monitor biomaterial-associated infections in small animal models. In this study, we directly compa...

journal_title：Acta biomaterialia

authors： Dinjaski N,Suri S,Valle J,Lehman SM,Lasa I,Prieto MA,García AJ

更新日期：2014-07-01 00:00:00

abstract：:The objective of our study was to evaluate the influence of prolonged artificial ageing on oxidation resistance and the subsequent wear behaviour of vitamin E-stabilized, in comparison to standard and highly cross-linked remelted polyethylene (XLPE), and the degradation effect of third-body particles on highly cross-l...

journal_title：Acta biomaterialia

authors： Grupp TM,Holderied M,Mulliez MA,Streller R,Jäger M,Blömer W,Utzschneider S

更新日期：2014-07-01 00:00:00

abstract：:Biodegradable metals have been suggested as revolutionary biomaterials for bone-grafting therapies. Of these metals, magnesium (Mg) and its biodegradable alloys appear to be particularly attractive candidates due to their non-toxicity and as their mechanical properties match those of bones better than other metals do....

journal_title：Acta biomaterialia

authors： Dorozhkin SV

更新日期：2014-07-01 00:00:00

abstract：:Myocardial infarction (MI) leads to the loss of cardiomyocytes, followed by left ventricular (LV) remodeling and cardiac dysfunction. The authors hypothesize that an elastic, biodegradable nanofibrous cardiac patch loaded with mesenchymal stem cells (MSC) could restrain LV remodeling and improve cardiac function after...

journal_title：Acta biomaterialia

authors： Kai D,Wang QL,Wang HJ,Prabhakaran MP,Zhang Y,Tan YZ,Ramakrishna S

更新日期：2014-06-01 00:00:00

abstract：:Despite the critical role tendons play in transmitting loads throughout the musculoskeletal system, little is known about the microstructural mechanisms underlying their mechanical function. Of particular interest is whether collagen fibrils in tendon fascicles bear load independently or if load is transferred between...

journal_title：Acta biomaterialia

authors： Szczesny SE,Elliott DM

更新日期：2014-06-01 00:00:00

abstract：:Hydrogels can provide a suitable environment for tissue formation by embedded cells, which makes them suitable for applications in regenerative medicine. However, hydrogels possess only limited mechanical strength, and must therefore be reinforced for applications in load-bearing conditions. In most approaches the rei...

journal_title：Acta biomaterialia

authors： Boere KW,Visser J,Seyednejad H,Rahimian S,Gawlitta D,van Steenbergen MJ,Dhert WJ,Hennink WE,Vermonden T,Malda J

更新日期：2014-06-01 00:00:00

abstract：:Antibacterial and remineralizing dental composites and adhesives were recently developed to inhibit biofilm acids and combat secondary caries. It is not clear what effect these materials will have on dental pulps in vivo. The objectives of this study were to investigate the antibacterial and remineralizing restoration...

journal_title：Acta biomaterialia

authors： Li F,Wang P,Weir MD,Fouad AF,Xu HH

更新日期：2014-06-01 00:00:00

abstract：:Cardiac fibrosis, an important pathological feature of structural remodeling, contributes to ventricular stiffness, diastolic dysfunction, arrhythmia and may even lead to sudden death. Matrix stiffness, one of the many mechanical factors acting on cells, is increasingly appreciated as an important mediator of myocardi...

journal_title：Acta biomaterialia

authors： Xie J,Zhang Q,Zhu T,Zhang Y,Liu B,Xu J,Zhao H

更新日期：2014-06-01 00:00:00

abstract：:In this study, one-step enzyme-mediated preparation of a multi-functional injectable hyaluronic-acid-based hydrogel system is reported. Hydrogel was formed through the in situ coupling of phenol moieties by horseradish peroxidase (HRP) and hydrogen peroxide (H2O2), and bioactive peptides were simultaneously conjugated...

journal_title：Acta biomaterialia

authors： Wang LS,Lee F,Lim J,Du C,Wan AC,Lee SS,Kurisawa M

更新日期：2014-06-01 00:00:00

abstract：:Decades of research have been undertaken towards the goal of tissue engineering using xenogeneic scaffolds. The primary advantages associated with use of xenogeneic tissue-derived scaffolds for in vitro development of replacement tissues and organs stem from the inherent extracellular matrix (ECM) composition and arch...

journal_title：Acta biomaterialia

authors： Wong ML,Griffiths LG

更新日期：2014-05-01 00:00:00

abstract：:Mast cells (MCs)_are recognized for their functional role in wound-healing and allergic and inflammatory responses - host responses that are frequently detrimental to implanted biomaterials if extended beyond acute reactivity. These tissue reactions impact especially on the performance of sensing implants such as cont...

journal_title：Acta biomaterialia

authors： Avula MN,Rao AN,McGill LD,Grainger DW,Solzbacher F

更新日期：2014-05-01 00:00:00

abstract：:The formation of new blood vessels has been shown to be fundamental in the repair of many damaged tissues, and we have recently shown that the adult human periodontal ligament contains multipotent stem/progenitor cells that are capable of undergoing vasculogenic and angiogenic differentiation in vitro and ex vivo. Ena...

journal_title：Acta biomaterialia

authors： Amin HD,Olsen I,Knowles J,Dard M,Donos N

更新日期：2014-05-01 00:00:00